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Updated: Feb 21, 2026
07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.5K
Research progress in modern structure of platinum complexes
Linkui Bai1, Chuanzhu Gao1, Qinghua Liu1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
European Journal of Medicinal Chemistry
|October 7, 2017
Summary
New platinum anticancer drugs are being developed to improve efficacy and reduce side effects. This review highlights recent platinum complexes with novel structures and ligands showing promising antitumor activity.
Area of Science:
- Medicinal Chemistry
- Oncology
- Pharmacology
Background:
- Cisplatin, discovered in 1967, established platinum-based drugs as crucial in cancer chemotherapy.
- Limitations of current platinum drugs include severe side effects and cross-drug resistance.
- Research focuses on developing novel platinum agents with enhanced antitumor activity and reduced toxicity.
Purpose of the Study:
- To review recent advancements in platinum-based anticancer complexes.
- To highlight complexes with diverse ligand types and modern structures.
- To identify promising candidates for novel anticancer agents.
Main Methods:
- Comprehensive literature review of recently reported platinum-based anticancer complexes.
- Categorization of complexes based on ligand types (e.g., amine carriers, leaving groups, steric hindrance).
- Inclusion of non-covalently binding Pt(II) complexes, Pt(IV) complexes, and polynuclear platinum complexes.
Main Results:
- Numerous platinum complexes with excellent anticancer activity have been synthesized and investigated.
- Diverse ligand strategies are employed to modulate activity and toxicity.
- Specific examples include complexes with amine carrier ligands, varied leaving groups, and steric hindrance.
Conclusions:
- Recent platinum-based anticancer complexes show significant potential as next-generation chemotherapeutics.
- Structural modifications and ligand design are key to overcoming current drug limitations.
- Further investigation of these novel complexes in vitro and in vivo is warranted.
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