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Related Experiment Videos

A new treatment for urethral strictures.

E J Milroy1, C R Chapple, J E Cooper

  • 1Department of Urology, Middlesex Hospital, London.

Lancet (London, England)
|June 25, 1988
PubMed
Summary

This study shows that a self-expanding stainless steel urethral stent, adapted from endovascular use, successfully treated urethral strictures in eight patients. All patients maintained a good caliber urethra one year post-implantation with complete epithelial coverage.

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Area of Science:

  • Urology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Urethral strictures pose significant challenges in urological practice.
  • Existing treatments for urethral strictures have limitations.
  • Endovascular stent technology offers potential for novel reconstructive solutions.

Purpose of the Study:

  • To evaluate the safety and efficacy of an endovascularly-derived self-expanding stent for treating urethral strictures.
  • To assess the long-term patency and biocompatibility of the implanted urethral stent.

Main Methods:

  • A self-expanding tubular mesh stent, made of surgical-grade stainless steel and originally designed for endovascular use, was implanted in eight patients.
  • Experimental studies were conducted in canine urethras prior to human implantation.

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  • Patients were followed for 6 months to 1 year postoperatively, with assessments including urethroscopy.

    • Main Results:

    • All eight patients demonstrated a good urethral caliber at follow-up (mean 8 months).
    • Urethroscopy revealed complete epithelialization of the stent implant within 4-6 months post-implantation.
    • The self-expanding stent facilitated restoration and maintenance of urethral patency.

    Conclusions:

    • The endovascularly-derived self-expanding urethral stent is a safe and effective option for managing urethral strictures.
    • Complete epithelialization suggests good biocompatibility and integration of the stent.
    • This innovative approach holds promise for improving outcomes in urethral reconstructive surgery.