Related Experiment Video
Updated: Feb 21, 2026
Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
The impact of transcatheter aortic valve implantation on quality of life: A mixed methods study
Felicity Astin1, Judith Horrocks2, Jim McLenachan3
1Centre for Applied Health Research, School of Human and Health Sciences, University of Huddersfield, UK; Research and Development, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, UK.
Objective:
To provide an in-depth understanding of patients' views about the impact of transcatheter aortic valve implantation on self-reported quality of life.
Background:
Transcatheter aortic valve implantation is considered to be the gold standard of care for inoperable patients diagnosed with severe symptomatic aortic stenosis. Mid- to long-term clinical outcomes are favourable and questionnaire data indicates improvements in quality of life but an in-depth understanding of how quality of life is altered by the intervention is missing.
Methods:
A mixed methods study design with a total of 89 in-depth qualitative interviews conducted with participants (39% male; mean age 81.7 years), 1 and 3 months post TAVI, recruited from a regional centre in England. Data were triangulated with questionnaire data (SF-36 and EQ5D-VAS) collected, pre, 1 and 3 months post implantation.
Results:
Participants' accounts were characterised by four key themes; shortened life, extended life, limited life and changed life. Quality of life was changed through two mechanisms. Most participants reported a reduced symptom burden and all explained that their life expectancy was improved. Questionnaire data supported interview data with gradual improvements in mean EQ-5D scores and SF-36 physical and mental domain scores at 1 and 3 months compared to baseline.
Conclusion:
Findings suggest that TAVI was of variable benefit, producing considerable improvements in either mental or physical health in many participants, while a smaller proportion continued to deteriorate.
