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Association between mismatch negativity and global functioning is specific to duration deviance in early stages of

Daisuke Koshiyama1, Kenji Kirihara1, Mariko Tada1

  • 1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Schizophrenia Research
|October 8, 2017
PubMed
Abstract

Insights

Duration Mismatch Negativity (dMMN) is linked to global functioning in early psychosis, unlike frequency MMN. This suggests dMMN is a valuable biomarker for early intervention in schizophrenia and ultra-high risk groups.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomarkers

Background:

  • Mismatch negativity (MMN) shows potential as an early biomarker for psychosis.
  • Previous research linked duration MMN (dMMN) to cognitive deficits and functional outcomes in chronic schizophrenia.
  • The impact of deviant MMN types and clinical stages on psychosis progression remained under-investigated.

Purpose of the Study:

  • To explore the relationship between dMMN, frequency MMN (fMMN), global functioning, and cognitive function in early psychosis stages.
  • To compare these relationships across individuals with recent-onset schizophrenia (ROSZ), ultra-high risk (UHR) for psychosis, and healthy controls.

Main Methods:

  • Investigated dMMN and fMMN in 26 ROSZ, 30 UHR, and 20 healthy control participants.
  • Utilized correlational analyses to assess links between MMN amplitudes, global functioning (GAF scale), and working memory.
  • Employed path analyses to determine direct effects of dMMN and fMMN on functioning and cognition.

Main Results:

  • dMMN amplitude was impaired in ROSZ compared to controls and correlated with global functioning in ROSZ (r=-0.45) and UHR (r=-0.37) groups.
  • fMMN amplitude did not differ between groups but correlated with working memory in the ROSZ group (r=-0.57).
  • Path analyses confirmed dMMN directly impacts global functioning in ROSZ and UHR, while fMMN directly impacts working memory only in ROSZ.

Conclusions:

  • The association between MMN and global functioning is specific to duration deviants and evident in early psychosis.
  • dMMN serves as a valuable biological marker for identifying early psychosis.
  • Findings support using dMMN to guide targeted treatment interventions in early psychosis.
Keywords:
Cognitive functionGlobal assessment of functioning (GAF)Mismatch negativity (MMN)Recent-onset schizophreniaUltra-high riskWorking memory

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