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HDL functionality in familial hypercholesterolemia: effects of treatment modalities and pharmacological interventions

Shiva Ganjali1, Amir Abbas Momtazi-Borojeni2, Maciej Banach3

  • 1Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Drug Discovery Today
|October 8, 2017
PubMed

Insights

Assessing high-density lipoprotein (HDL) functionality offers better cardiovascular risk evaluation than cholesterol levels alone. This review examines how lipid-modifying therapies affect HDL functionality in familial hypercholesterolemia (FH).

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Pharmacology

Background:

  • High-density lipoprotein (HDL) cholesterol measurement is less effective than HDL functionality assessment for evaluating cardiovascular risk.
  • Familial hypercholesterolemia (FH) is characterized by qualitative HDL particle abnormalities, presenting potential therapeutic targets.
  • Optimizing HDL functionality may offer a novel treatment strategy for FH.

Purpose of the Study:

  • To review the impact of various lipid-modifying therapies on HDL functionality in patients with FH.
  • To address the gap in comprehensive reviews on this specific topic.

Main Methods:

  • Literature review of studies investigating lipid-modifying therapies and HDL functionality in FH patients.
  • Synthesis of existing data on HDL particle quality and therapeutic interventions.

Main Results:

  • (Not applicable for a review article, results are synthesized from existing studies)

Conclusions:

  • Understanding the effects of lipid-modifying therapies on HDL functionality is crucial for developing effective FH treatments.
  • Further research is needed to fully elucidate the therapeutic potential of targeting HDL functionality in FH.

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