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Related Experiment Video

Updated: Feb 21, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

Pig models on intestinal development and therapeutics.

Lanmei Yin¹, Huansheng Yang^2,3, Jianzhong Li¹

¹Animal Nutrition and Human Health Laboratory, School of Life Sciences, Hunan Normal University, Changsha City, 410081, Hunan, China.

|October 8, 2017

Summary

This summary is machine-generated.

The piglet is an excellent animal model for studying human gastrointestinal diseases due to its similar anatomy and digestive processes. This review highlights its utility in understanding intestinal health, development, and potential therapeutic strategies.

Keywords:

Gastrointestinal tract Human gastrointestinal diseases Microflora Pediatric nutrition Pig models

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Area of Science:

Gastroenterology and Animal Modeling

Background:

The gastrointestinal tract is crucial for nutrient absorption and overall health.
Understanding gastrointestinal diseases requires appropriate animal models.
The piglet shares significant physiological and anatomical similarities with humans.

Purpose of the Study:

To review the piglet as a translational model for human intestinal development and health.
To explore the piglet model's application in studying gastrointestinal disease pathogenesis.
To provide a basis for research in mammalian nutrition, health, disease, and therapeutics.

Main Methods:

Literature review focusing on piglet physiology and comparative anatomy.
Analysis of studies utilizing piglets for gastrointestinal and neurodevelopmental research.
Examination of piglet models in organ transplantation research.

Main Results:

Piglets exhibit comparable anatomy, nutritional needs, and digestive processes to humans.
The piglet's intestinal microbial ecosystem mirrors the human counterpart.
Similarities extend to brain development, making piglets valuable for pediatric nutrition studies.

Conclusions:

The piglet serves as a highly relevant animal model for human gastrointestinal research.
Its utility spans disease pathogenesis, development, nutrition, and organ transplantation.
Further research leveraging the piglet model can advance human health and therapeutic strategies.