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Review on antioxidants and evaluation procedures.

Suresh Kumar1,2, Sunil Sharma3, Neeru Vasudeva3

  • 1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India. pharm.vermasuresh@gmail.com.

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Antioxidants protect tissues from oxidative damage and may prevent chronic diseases. This review covers oxidants, antioxidants, and methods for evaluating antioxidant activity in new compounds and natural sources.

Keywords:
antioxidantsdiphenyl-picryl-hydrazylherbal antioxidantsin vivo antioxidant modelsvitamins

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Nutrition Science

Background:

  • Oxidation is a physiological process in animal tissues that can cause cellular damage.
  • Antioxidants, including nutrients and enzymes, counteract these damaging effects.
  • Oxidative stress is implicated in numerous chronic diseases such as cancer, diabetes, and neurodegenerative disorders.

Purpose of the Study:

  • To provide a comprehensive overview of oxidants and antioxidants.
  • To discuss the mechanisms, functions, and adverse effects of antioxidants.
  • To review in vivo and in vitro models for evaluating antioxidant activity.

Main Methods:

  • Literature review of scientific articles on oxidants and antioxidants.
  • Synthesis of information regarding the definition, types, and sources of antioxidants.
  • Compilation of various experimental models used for antioxidant activity assessment.

Main Results:

  • Detailed explanation of the role of antioxidants in preventing chronic diseases.
  • Elucidation of the mechanisms by which antioxidants exert their effects.
  • Presentation of diverse methods for evaluating the biological activity of antioxidant compounds.

Conclusions:

  • Antioxidants are crucial for mitigating oxidative damage and preventing disease.
  • Understanding antioxidant mechanisms and evaluation methods is vital for research.
  • This review serves as a valuable resource for researchers in the field of antioxidant discovery and evaluation.