Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consistency of stream insect trait responses to instream pesticide exposure across five U.S. regions.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders.

Scientific reports·2025
Same author

Identification and Characterization of a Small-Molecule Inhibitor of the <i>Pseudomonas aeruginosa</i> SOS Response.

ACS infectious diseases·2025
Same author

Protection Efficacy of Antibacterial Strains against Fire Blight Caused by Erwinia amylovora on Apple Blossom.

The plant pathology journal·2024
Same author

Reducing work-related stress among health professionals by using a training-based intervention programme for leaders in a cluster randomised controlled trial.

Scientific reports·2024
Same author

Nursing Leaders' Knowledge and Awareness of Bullying and Lateral Violence: A Qualitative Study.

SAGE open nursing·2024

Related Experiment Video

Updated: Feb 21, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.9K

Studies of Lassa Virus Cell Entry.

Antonella Pasquato1, Antonio Herrador Fernandez1, Stefan Kunz2

  • 1Institute of Microbiology, University Hospital Center, University of Lausanne, Rue du Bugnon 48, CH-1011, Lausanne, Switzerland.

Methods in Molecular Biology (Clifton, N.J.)
|October 8, 2017
PubMed
Summary

Lassa virus (LASV) uses multiple cell receptors for entry, including LAMP1, via a unique endocytosis pathway. Researchers investigated this process to find new antiviral therapies targeting viral entry.

Keywords:
EndocytosisEndosomeInhibitorLassa virusReceptorViral entry

More Related Videos

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.5K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.8K

Related Experiment Videos

Last Updated: Feb 21, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.9K
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.5K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.8K

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Viral entry is crucial for infection and a target for therapeutics.
  • Lassa virus (LASV) utilizes cell receptors like dystroglycan, TAM receptors, and C-type lectins for host cell entry.
  • LASV entry involves a clathrin- and dynamin-independent pathway to late endosomes, requiring LAMP1 for fusion.

Purpose of the Study:

  • To investigate the mechanisms of Lassa virus cell entry.
  • To identify and test potential inhibitors of LASV entry.

Main Methods:

  • Experimental approaches to study LASV cell entry.
  • Testing candidate inhibitors for antiviral activity against LASV entry.

Main Results:

  • Detailed characterization of LASV's receptor usage and entry pathway.
  • Identification of key steps in LASV cell entry.

Conclusions:

  • Understanding LASV entry is vital for controlling zoonotic transmission and viral emergence.
  • Targeting LASV entry presents a promising therapeutic strategy.