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Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Related Experiment Video

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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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EEG for children with complex febrile seizures.

Pankaj B Shah1, Saji James, S Elayaraja

  • 1Department of Community Medicine, Sri Ramachandra Medical College and Research Institute, Sri. Ramachandra University, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, India, 600116.

The Cochrane Database of Systematic Reviews
|October 8, 2017
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No randomized controlled trials were found to support or refute the use of electroencephalographs (EEG) for children with complex febrile seizures. Further research is needed to establish EEG

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Area of Science:

  • Pediatric Neurology
  • Clinical Neurophysiology
  • Evidence-Based Medicine

Background:

  • Complex febrile seizures in children under five are characterized by prolonged duration, recurrence, or focal neurological signs.
  • Electroencephalography (EEG) is often recommended by clinicians for evaluating complex febrile seizures, despite limited supporting evidence.
  • The optimal timing and utility of EEG after complex febrile seizures remain areas of clinical uncertainty.

Purpose of the Study:

  • To systematically assess the evidence regarding the use and timing of electroencephalography (EEG) in children under five years old who have experienced complex febrile seizures.
  • To evaluate the diagnostic utility and clinical impact of EEG in this pediatric population.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases, including Cochrane Epilepsy Group Specialized Register, CENTRAL, MEDLINE, and ClinicalTrials.gov, up to January 2017.
  • The review included only randomized controlled trials (RCTs) that investigated the utility and timing of EEG after complex febrile seizures in children.
  • Study selection, data extraction, and quality assessment were performed independently by multiple reviewers, with disagreements resolved through consensus.

Main Results:

  • Out of 41 potentially eligible studies identified, no randomized controlled trials (RCTs) met the inclusion criteria for this review.
  • The current evidence base lacks high-quality RCTs to either support or refute the routine use of EEG following complex febrile seizures in young children.
  • No new relevant studies were identified since the previous version of this review.

Conclusions:

  • There is a significant lack of evidence from randomized controlled trials to guide the clinical use of EEG in children with complex febrile seizures.
  • Future research, specifically well-designed RCTs with adequate sample sizes, is necessary to determine the true value and appropriate timing of EEG in this context.
  • The current practice of recommending EEG for complex febrile seizures is not supported by robust scientific evidence from RCTs.