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Exploration of ethyl anthranilate-loaded monolithic matrix-type prophylactic polymeric patch.

Johirul Islam^1,2, Kamaruz Zaman², Srijita Chakrabarti¹

¹Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, Assam, India.

Journal of Food and Drug Analysis

|October 9, 2017

Summary

This study evaluated the stability of volatile ethyl anthranilate in polymeric patches for disease prevention. The optimized patches demonstrated excellent stability and low residual solvent levels, ensuring formulation integrity.

Keywords:

Controlled release Ethyl 2-aminobenzoate ICH guidelines Insect repellent Polymeric patch

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Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Delivery Systems

Background:

Volatile compounds in pharmaceutical formulations pose stability challenges.
Developing stable delivery systems for volatile agents is crucial for effective prophylaxis.

Purpose of the Study:

To assess the stability of matrix-type polymeric patches containing volatile ethyl anthranilate.
To ensure the efficacy of these patches for prophylaxis against vector-borne diseases.

Main Methods:

Fabrication of ethyl anthranilate-loaded matrix-type polymeric patches using solvent evaporation.
Stability testing according to International Conference on Harmonization (ICH) guidelines for six months under accelerated conditions.
Quantification of residual solvents as per ICH guidelines.

Main Results:

Optimized patches exhibited superior stability, drug content uniformity, and physical appearance after six months.
Residual solvent levels were found to be well below the accepted limits.
Analytical parameters confirmed the stability of the volatile compound within the polymeric matrix.

Conclusions:

Matrix-type polymeric patches offer a stable formulation for volatile compounds like ethyl anthranilate.
The developed patches are suitable for prophylaxis against vector-borne diseases.
Established analytical parameters are vital for ensuring the stability of volatile compound delivery devices.