Volume fractions of DCE-MRI parameter as early predictor of histologic response in soft tissue sarcoma: A feasibility...

To find early predictors of histologic response in soft tissue sarcoma through volume transfer constant (K^trans) analysis based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

11 Patients with soft tissue sarcoma of the lower extremity that underwent preoperative chemoradiotherapy followed by limb salvage surgery were included in this retrospective study. For each patient, DCE-MRI data sets were collected before and two weeks after therapy initiation, and histologic tumor cell necrosis rate (TCNR) was reported at surgery. The DCE-MRI volumes were aligned by registration. Then, the aligned volumes were used to obtain the K^trans variation map. Accordingly, three sub-volumes (with increased, decreased or unchanged K^trans) were defined and identified, and fractions of the sub-volumes, denoted as F₊, F_- and F₀, respectively, were calculated. The predictive ability of volume fractions was determined by using area under a receiver operating characteristic curve (AUC). Linear regression analysis was performed to investigate the relationship between TCNR and volume fractions. In addition, the K^trans values of the sub-volumes were compared.

The AUC for F_- (0.896) and F₀ (0.833) were larger than that for change of tumor longest diameter ΔD (0.625) and the change of mean K^transΔK^trans¯ (0.792). Moreover, the regression results indicated that TCNR was directly proportional to F₀ (R²=0.75, P=0.0003), while it was inversely proportional to F_- (R²=0.77, P=0.0002). However, TCNR had relatively weak linear relationship with ΔK^trans¯ (R²=0.64, P=0.0018). Additionally, TCNR did not have linear relationship with DD (R²=0.16, P=0.1246).

The volume fraction F_- and F₀ have potential as early predictors of soft tissue sarcoma histologic response.