Related Experiment Video
Updated: Feb 21, 2026
Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease
Veronica Wendy Setiawan1, Kristine Monroe1, Aurelia Lugea1
1Veronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.
Abstract:
Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease. Understanding the effects of alcohol use on the pancreas may prove beneficial in the prevention of both pancreatitis and pancreatic cancer.
