Related Experiment Video For Glucose transporter 1
Updated: Feb 12, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma
Matyas Abel Tsegaye1, Zachary T Schafer1
1Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Abstract:
A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis.
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