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Updated: Feb 21, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing
Arnaud Lubin1, Sheng Sheng2, Deirdre Cabooter3
1Discovery Sciences, Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Abstract:
Lack of knowledge on the expected concentration range or insufficient linear dynamic range of the analytical method applied are common challenges for the analytical scientist. Samples that are above the upper limit of quantification are typically diluted and reanalyzed. The analysis of undiluted highly concentrated samples can cause contamination of the system, while the dilution step is time consuming and as the case for any sample preparation step, also potentially leads to precipitation, adsorption or degradation of the analytes.
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