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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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[A case of pulmonary alternariosis complicated with aspergillosis]

Yixin Tan1, Min Song2, Hong Peng2

  • 1Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|October 10, 2017
PubMed

Insights

A 61-year-old woman with pulmonary fungal infections, including pulmonary alternariosis and aspergillosis, experienced symptom recovery after antifungal treatment. This case highlights successful management of rare co-existing pulmonary mycoses.

Area of Science:

  • Pulmonology
  • Mycology
  • Infectious Diseases

Background:

  • Pulmonary fungal infections, such as aspergillosis and alternariosis, can present with severe respiratory symptoms.
  • Co-infection with multiple fungal species is rare but poses diagnostic and therapeutic challenges.
  • Recurrent hemoptysis and cough are significant clinical manifestations requiring thorough investigation.

Observation:

  • A 61-year-old female patient experienced 3 years of recurrent hemoptysis and cough.
  • Fungal culture identified Alternaria, while biopsy confirmed pulmonary aspergillosis.

Findings:

  • The patient received a 7-day course of intravenous voriconazole, followed by 11 days of intravenous amphotericin B.
  • Oral voriconazole treatment upon discharge led to complete recovery from hemoptysis and cough.
  • Post-treatment lung CT scans revealed normalization of lung parenchyma.

Implications:

  • This case highlights the successful management of a rare pulmonary co-infection with Alternaria and Aspergillus.
  • Aggressive antifungal treatment, including voriconazole and amphotericin B, can be effective in resolving severe pulmonary mycoses.
  • Prompt diagnosis and tailored therapy are crucial for favorable outcomes in patients with complex fungal lung infections.

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