Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux.

bioRxiv : the preprint server for biology·2026
Same author

Scalable networks of multimodal haptic arrays for plantar sensory substitution.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Recombinant Bombali ebolavirus in cynomolgus macaques as a survival model of Ebola virus disease.

Nature communications·2026
Same author

Wireless, skin-interfaced multimodal sensing system for continuous psychophysiological monitoring-A wearable polygraph device.

Science advances·2026
Same author

Shear cytokine crosstalk is a determinant of SARS-CoV-2-induced endothelial pathophysiology and thrombosis in human vessel chips.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Wearable SENsor to Diagnose and Assess SEverity of Aortic Stenosis (SENSE-AS): A Proof-of-Concept Study.

JACC. Advances·2026

Related Experiment Video

Updated: Feb 21, 2026

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy
08:54

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy

Published on: June 5, 2019

8.0K

Robust Visualization and Discrimination of Nanoparticles by Interferometric Imaging.

Jacob Trueb1, Oguzhan Avci2, Derin Sevenler3

  • 1Department of Mechanical Engineering Boston University, 8 St. Mary's Street, Boston, MA 02215.

IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-Optics Society
|October 10, 2017
PubMed
Summary

Digital biosensors enable precise detection of single nanoparticles for advanced diagnostics. This study enhances the single-particle interferometric reflectance imaging sensor (SP-IRIS) for improved nanoparticle counting and medical applications.

Keywords:
Optical biosensingdigital detectioninterferometrynanoparticle imagingsingle particle detection

More Related Videos

Implementation of a Reference Interferometer for Nanodetection
16:11

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

9.8K
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

2.4K

Related Experiment Videos

Last Updated: Feb 21, 2026

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy
08:54

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy

Published on: June 5, 2019

8.0K
Implementation of a Reference Interferometer for Nanodetection
16:11

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

9.8K
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

2.4K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Optical Biosensing

Background:

  • Digital biosensors offer superior detection limits by counting individual biomolecules or nanoparticles.
  • Single-nanoparticle detection is crucial for advancing diagnostic capabilities.
  • Traditional ensemble measurements often fall short of the sensitivity required for certain diagnostic applications.

Purpose of the Study:

  • To review optical techniques for single nanoparticle detection.
  • To describe the single-particle interferometric reflectance imaging sensor (SP-IRIS).
  • To present engineering improvements for reliable faint nanoparticle detection using SP-IRIS for medical diagnostics.

Main Methods:

  • Review of modern optical techniques for single nanoparticle detection.
  • Description of the single-particle interferometric reflectance imaging sensor (SP-IRIS).
  • Development of image acquisition and processing methods to enhance nanoparticle detection and counting accuracy.

Main Results:

  • A novel image acquisition processing method was developed for discriminating and accurately counting nanoparticles.
  • The new method significantly reduces false positives and false negatives in nanoparticle detection.
  • Engineering improvements enhance the reliability of detecting faint nanoparticles with SP-IRIS.

Conclusions:

  • The enhanced SP-IRIS system offers improved accuracy in nanoparticle enumeration.
  • These advancements are critical for translating SP-IRIS technology into clinical diagnostic tools.
  • The improved digital biosensor approach holds significant promise for future medical diagnostics.