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Updated: Feb 21, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
The use of daily electronic prompts to help improve antimicrobial stewardship in a critical care unit
P A Allan1, M J Newman2, R Oehmen3
1Critical Care Department, Fiona Stanley Hospital, Perth, Western Australia, Australia.
Introduction:
Antimicrobial resistance (AMR) represents a growing threat to public health, with the potential to reverse many of the gains made in modern medicine. AMR is contributed to by both inappropriate choice of antibiotics and inappropriate antibiotic course durations.
Objectives:
The objective of this audit was to determine if the introduction of antimicrobial prescribing electronic prompts in an electronic patient record had a positive impact on antimicrobial stewardship.
Methods:
The audit examined the proportion of antibiotic prescriptions within a critical care unit in which both a valid stop date and indication were recorded. The audit was repeated on two occasions: first, after an education programme, and second, after the introduction of an electronic prompt within the patients' electronic patient record.
Results:
Chi-square analyses indicated that significant improvements in both the recording of indications (χ²(4) = 39.69, P <0.0001) and stop-dates (χ²(4) = 42.10, P <0.0001) occurred across the three audits.
Conclusion:
We conclude that the novel use of daily electronic prompts has a positive impact on antimicrobial stewardship.
Insights
Electronic prompts improved antimicrobial stewardship by increasing the recording of antibiotic indications and stop dates. This intervention supports safer antibiotic use and combats antimicrobial resistance (AMR).
Area of Science:
- Public Health
- Infectious Diseases
- Health Informatics
Background:
- Antimicrobial resistance (AMR) is a significant global health threat, jeopardizing modern medical advancements.
- Inappropriate antibiotic selection and duration of treatment are key contributors to the rise of AMR.
Purpose of the Study:
- To evaluate the impact of electronic prescribing prompts on antimicrobial stewardship.
- To assess improvements in antibiotic prescribing practices within a critical care unit.
Main Methods:
- An audit of antibiotic prescriptions in a critical care unit was conducted.
- The audit focused on the recording of valid stop dates and indications for antibiotic prescriptions.
- The audit was performed in three phases: baseline, post-education, and post-implementation of electronic prompts.
Main Results:
- Significant improvements were observed in the recording of both antibiotic indications and stop dates across the three audit phases.
- Statistical analysis (Chi-square) confirmed the significance of these improvements (P <0.0001 for both indications and stop dates).
Conclusions:
- The implementation of daily electronic prompts positively impacts antimicrobial stewardship.
- This novel approach effectively enhances the quality of antibiotic prescribing in critical care settings.
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