[Effects of cordanum and propranolol on coronary resistance]

The effects of cordanum and propranolol on the coronary resistance were studied in isolated cat hearts. The infusion of cordanum and propranolol may be followed by both reduction or enlargement of the coronary resistance. The alterations of the coronary resistance are in most cases parallel with the weakening of the isolated heart function. In some cases cordanum infusion is followed by a short-term reduction in the coronary resistance, which precedes the alteration of the heart function and thus may be due to direct cordanum effect on the coronary vessels.