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Related Experiment Video

Updated: Feb 21, 2026

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

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Corn silk extract improves benign prostatic hyperplasia in experimental rat model.

So Ra Kim1, Ae Wha Ha2, Hyun Ji Choi1

  • 1Department of Food Science and Nutrition, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea.

Nutrition Research and Practice
|October 10, 2017
PubMed
Summary
This summary is machine-generated.

Corn silk extract effectively improved benign prostatic hyperplasia (BPH) symptoms in rats by reducing prostate weight, dihydrotestosterone (DHT), and prostate-specific antigen (PSA) levels. This natural remedy shows promise for BPH management.

Keywords:
ProstateZea maysfinasteridemaysintestosterone

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Area of Science:

  • Pharmacology
  • Urology
  • Natural Product Research

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Testosterone propionate is used to induce BPH in experimental models.
  • Current treatments for BPH have limitations, necessitating exploration of natural alternatives.

Purpose of the Study:

  • To investigate the therapeutic potential of corn silk extract (CSE) in a rat model of BPH.
  • To evaluate the effects of CSE on key biomarkers associated with BPH progression.

Main Methods:

  • Male Wistar rats were induced with BPH using testosterone propionate.
  • Experimental groups received varying doses of corn silk extract or finasteride.
  • Prostate weight, serum/tissue DHT, 5α-reductase 2 (5α-R2), and prostate-specific antigen (PSA) were measured.
  • mRNA expression of 5α-R2 and PCNA was analyzed.

Main Results:

  • Corn silk extract significantly reduced prostate weight, serum DHT, 5α-R2, and PSA levels compared to the testosterone-only group.
  • CSE treatment inhibited 5α-R2 mRNA expression and dose-independently decreased PCNA mRNA expression.
  • These effects were comparable to the established BPH drug, finasteride.

Conclusions:

  • Corn silk extract demonstrates significant efficacy in ameliorating BPH symptoms in a preclinical model.
  • CSE acts by inhibiting 5α-reductase 2 activity and reducing key BPH-related markers.
  • Corn silk extract represents a promising natural therapeutic agent for managing benign prostatic hyperplasia.