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Universal sensor array for highly selective system identification using two-dimensional nanoparticles.

Mustafa Salih Hizir1, Neil M Robertson1, Mustafa Balcioglu1

  • 1Department of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , USA . Email: myigit@albany.edu ; Tel: +1-518-442-3002.

Chemical Science
|October 10, 2017
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Summary
This summary is machine-generated.

This study introduces a universal sensor array using 2D nanoparticles and DNA for sensitive detection. The array successfully identifies proteins, cancer cells, and molecular events with high accuracy.

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Area of Science:

  • Nanotechnology
  • Biomedical Sensing
  • Materials Science

Background:

  • Traditional sensing methods are limited by relying on specific interactions.
  • Richer information can be obtained by analyzing non-specific intermolecular forces.
  • A universal sensing platform is needed for diverse detection challenges.

Purpose of the Study:

  • To develop a highly selective universal sensor array using water-soluble 2D nanoparticles and fluorescent DNA.
  • To demonstrate the array's capability in identifying diverse biological systems.
  • To leverage non-covalent interactions for robust and tunable nanoprobe assembly.

Main Methods:

  • Assembled a sensor array with 12 fluorescently silent non-specific nanoreceptors (2D nanoparticles: nGO, MoS2, WS2).
  • Utilized fluorescent DNA molecules as probes for target interaction.
  • Employed Partial Least Squares (PLS) discriminant analysis for data processing.

Main Results:

  • Successfully identified and clustered three distinct systems: proteins, live breast cancer cells, and macromolecule structure-switching events.
  • Achieved 95% confidence without overlap for all tested systems.
  • Accurately predicted concentrations for 14 out of 15 unknown protein samples and identified 8 out of 9 unknown cell samples.

Conclusions:

  • The developed sensor array offers a powerful and universal approach to detection by analyzing richer sensing information.
  • The use of unmodified 2D materials and ssDNA probes allows for simplicity, tunability, and limitless possibilities for sensor design.
  • This strategy is adaptable for a wide range of sensing applications beyond the systems studied.