Light-responsive paper strips as CO-releasing material with a colourimetric response
Upendar Reddy G1, Jingjing Liu1, Patrick Hoffmann2,3
1Institute for Inorganic and Analytical Chemistry (IAAC) , Friedrich Schiller University Jena , Humboldtstr. 8 , D-07743 Jena , Germany .
Chemical Science
|October 10, 2017
Summary
This study introduces CORM-Dabsyl, a light-activated molecule that releases carbon monoxide (CO) and changes color. This CO-releasing molecule shows potential for therapeutic applications with minimal toxicity.
Area of Science:
- Inorganic Chemistry
- Photochemistry
- Materials Science
Background:
- Carbon monoxide (CO) plays a vital role in human physiology.
- Molecules capable of controlled CO release are being explored as therapeutic agents.
Purpose of the Study:
- To develop a light-responsive carbon monoxide-releasing molecule (CORM) with a visible colorimetric response.
- To assess the therapeutic potential and safety of the novel CORM.
Main Methods:
- Synthesis and characterization of CORM-Dabsyl, a manganese tricarbonyl complex.
- Photochemical CO-release studies using 405 nm irradiation.
- Density Functional Theory (DFT) and Time-Dependent DFT (TD-DFT) calculations.
- In vitro toxicity assays on human cell lines (LX-2 and HepaRG®).
- Loading CORM-Dabsyl onto paper strips for visible CO release detection.
Main Results:
- CORM-Dabsyl demonstrated a distinct colorimetric change upon photochemical CO release.
- The molecule was stable in the dark but efficiently released CO upon 405 nm light exposure.
- Mild toxicity was observed for CORM-Dabsyl against human cell lines (IC50 ≈ 30 μM).
- CO release from paper strips loaded with CORM-Dabsyl was visually detectable.
Conclusions:
- CORM-Dabsyl is a promising light-responsive CO-releasing molecule with a visual indicator.
- The material exhibits low toxicity and can be immobilized on paper for practical applications.
- This development facilitates the use of CO-releasing materials in therapeutic contexts.
