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Updated: Feb 21, 2026

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Pair distribution functions of amorphous organic thin films from synchrotron X-ray scattering in transmission mode
Chenyang Shi1, Rattavut Teerakapibal2, Lian Yu2
1Drug Product Development, Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Abstract:
Using high-brilliance high-energy synchrotron X-ray radiation, for the first time the total scattering of a thin organic glass film deposited on a strongly scattering inorganic substrate has been measured in transmission mode. The organic thin film was composed of the weakly scattering pharmaceutical substance indomethacin in the amorphous state. The film was 130 µm thick atop a borosilicate glass substrate of equal thickness. The atomic pair distribution function derived from the thin-film measurement is in excellent agreement with that from bulk measurements. This ability to measure the total scattering of amorphous organic thin films in transmission will enable accurate in situ structural studies for a wide range of materials.
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