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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
Sangho Won1, Sarah-Jane Richards1, Marc Walker2
1Department of Chemistry , University of Warwick , Coventry , CV4 7AL , UK .
Nanoscale Horizons
|October 10, 2017
Abstract:
Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.
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