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Related Experiment Video

Updated: Feb 21, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Prepregnancy Hypothyroidism versus Gestational Hypothyroidism: A Comparative Study.

Prashant Ulhas Kaduskar1, Mala Dharmalingam1, Pramila Kalra1

  • 1Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.

Indian Journal of Endocrinology and Metabolism
|October 10, 2017
PubMed
Summary
This summary is machine-generated.

Pregnancy outcomes were similar for women with hypothyroidism diagnosed before or during pregnancy. Both overt and subclinical hypothyroidism did not significantly affect outcomes like birth weight or C-section rates.

Keywords:
Adverse pregnancy outcomesESI guidelinesgestational hypothyroidismprepregancy hypothyroidism

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Area of Science:

  • Endocrinology
  • Obstetrics
  • Reproductive Medicine

Background:

  • Inadequate management of hypothyroidism during pregnancy poses risks to mother and child.
  • Understanding pregnancy outcomes in regions with low thyroid disease awareness is crucial.

Purpose of the Study:

  • To compare demographic and biochemical features of prepregnancy hypothyroidism versus hypothyroidism diagnosed during pregnancy.
  • To assess and compare pregnancy outcomes between these two groups.

Main Methods:

  • Prospective study conducted in a tertiary care center over two years.
  • Patients categorized into prepregnancy hypothyroidism (Group I) and hypothyroidism diagnosed during pregnancy (Group II).
  • Subgroup analysis based on ESI guidelines for subclinical and overt hypothyroidism; Chi-square and Mann-Whitney tests used for statistical analysis.

Main Results:

  • 452 pregnant women with hypothyroidism analyzed; 371 delivered pregnancies evaluated.
  • Group II (hypothyroidism during pregnancy) had more patients (56.64%) than Group I (prepregnancy hypothyroidism, 43.36%).
  • No significant differences observed in pregnancy outcomes, including congenital hypothyroidism, birth weight, abortions, or cesarean sections, between Group I and Group II, or between overt and subclinical hypothyroidism subgroups.

Conclusions:

  • Patients with prepregnancy hypothyroidism presented earlier for testing, indicating better awareness.
  • Pregnancy outcomes were comparable between women with prepregnancy hypothyroidism and those diagnosed during pregnancy.
  • Neither overt nor subclinical hypothyroidism status significantly impacted pregnancy outcomes.