Related Experiment Video

Updated: Feb 21, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.1K

Left atrial volume changes are an early marker of end-organ damage in essential hypertension: A multidisciplinary

Batur Kanar1, Beste Ozben1, Hatice Selen Kanar2

  • 1Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|October 10, 2017
PubMed

Insights

Left atrial phasic volumes measured by RT3DE are linked to hypertensive end-organ damage. These measurements can help predict cardiovascular risks in patients with essential hypertension.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left atrial (LA) volume is a known predictor of adverse cardiovascular outcomes.
  • Essential hypertension (HT) can lead to end-organ damage (EOD).

Purpose of the Study:

  • To evaluate the relationship between LA phasic volumes and hypertensive EOD.
  • Utilize real-time three-dimensional echocardiography (RT3DE) for assessment in patients with essential HT.

Main Methods:

  • Included 95 essential hypertensive patients, categorized into three groups based on EOD presence (none, mild, severe).
  • Assessed LA phasic volumes using RT3DE and evaluated EOD through microalbuminuria and retinal vascular changes.

Main Results:

  • Significant differences in LA phasic volumes (maximal, minimal, pre-atrial contraction, total stroke, active stroke volume indices) were observed among groups (P < .001).
  • Worse LA reservoir and conduit functions correlated with more extensive EOD.
  • LA active stroke volume index independently predicted EOD with high sensitivity (82%) and specificity (92%) (AUC = 0.96, P < .001).

Conclusions:

  • RT3DE-measured LA phasic volumes and mechanical functions are associated with hypertensive EOD.
  • These parameters may serve as surrogate endpoints for cardiovascular mortality and morbidity in essential HT patients.
Abstract

Keywords:
hypertensionleft atrial volumethree-dimensional echocardiography

More Related Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
641
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
673
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
6.6K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
635