Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Somatostatinomas].

D Pinsard1, D Chadenas

  • 1Service d'Endocrinologie, CHR d'Orléans la Source, France.

Diabete & Metabolisme
|January 1, 1988
PubMed
Summary

Somatostatinomas are rare endocrine tumors secreting somatostatin, often found in the pancreas. Diagnosis involves plasma somatostatin testing and tumor immunocytochemistry, with treatment including surgery and chemotherapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Paresthetic notalgia and multiple endocrine neoplasia type 2a (Sipple's syndrome): 3 cases].

Annales de dermatologie et de venereologie·1999
Same author

Proximal deletions of the long arm of the Y chromosome suggest a critical region associated with a specific subset of characteristic Turner stigmata.

Human molecular genetics·1995
Same author

[Mediastinal parathyroid adenomas on a 5th ectopic gland. 2 case reports].

La Revue de medecine interne·1992
Same author

[Pseudotumoral form of subacute nodular thyroiditis].

Presse medicale (Paris, France : 1983)·1991
Same author

[Isolated acute kidney failure after attempted suicide with paracetamol].

Presse medicale (Paris, France : 1983)·1991
Same author

Counterregulatory response to insulin-induced hypoglycemia in trained and nontrained humans.

Metabolism: clinical and experimental·1990

Area of Science:

  • Endocrinology
  • Oncology
  • Gastroenterology

Background:

  • Somatostatinomas are rare neuroendocrine tumors characterized by excessive somatostatin secretion.
  • These tumors typically arise in the pancreas or digestive tract, but can occur in unusual locations like the bronchi.
  • Clinical manifestations are often non-specific and result from somatostatin hypersecretion, differing between pancreatic and digestive primary sites.

Purpose of the Study:

  • To review the characteristics, diagnosis, and treatment of somatostatinomas.
  • To highlight the clinical syndromes associated with somatostatinomas.
  • To discuss diagnostic modalities and therapeutic strategies for somatostatinomas.

Main Methods:

  • Review of 43 reported cases of somatostatinoma.
  • Analysis of clinical manifestations, diagnostic methods, and treatment outcomes.
  • Discussion of radioimmunoassay for plasma somatostatin and tumor immunocytochemistry.

Main Results:

  • Pancreatic somatostatinomas can cause diabetes mellitus, cholelithiasis, pancreatic exocrine insufficiency, gastric hypochlorhydria, and anemia.
  • Digestive somatostatinomas do not typically present with these specific symptoms.
  • Co-secretion of other hormonal peptides can alter clinical presentation.
  • Radioimmunoassay of plasma somatostatin and tumor immunocytochemistry are key diagnostic tools.

Conclusions:

  • Somatostatinomas have a poor prognosis but are amenable to curative treatment.
  • Surgical resection is a primary treatment option.
  • Chemotherapy regimens including streptozotocin and 5-fluorouracil are utilized.

Related Experiment Videos