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Updated: Feb 21, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Bisphenol A in Reproduction: Epigenetic Effects.
Rosanna Chianese1, Jacopo Troisi2,3, Sean Richards4
1Dipartimento di Medicina Sperimentale, Universita della Campania "Luigi Vanvitelli", Napoli, Italy.
Bisphenol A (BPA) exposure impacts male and female reproductive health through epigenetic changes. These effects can influence fertility and may even affect offspring across generations, highlighting the need for caution.
Area of Science:
- Endocrinology
- Reproductive Toxicology
- Epigenetics
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical prevalent in consumer products.
- BPA mimics estradiol, interfering with steroid signaling and impacting reproductive health.
- It is recognized as a reproductive toxicant with potential epigenetic effects.
Purpose of the Study:
- To review the effects of BPA on reproductive health.
- To summarize the epigenetic impacts of BPA on male and female reproduction.
Main Methods:
- Literature review of studies on BPA and reproductive health.
- Analysis of research on BPA's epigenetic mechanisms.
Main Results:
- BPA induces epigenetic changes affecting male reproduction, including spermatogenesis and sperm quality, with potential trans-generational impacts.
- BPA affects female reproduction, impacting ovarian function, embryo development, and gamete quality for fertilization.
- Epigenetic modifications like DNA methylation and histone alterations are implicated in BPA's reproductive toxicity.
Conclusions:
- BPA exposure, particularly during fetal and neonatal development, poses a risk to reproductive health.
- Understanding BPA's epigenetic mechanisms is crucial for preserving fertility in both sexes.
- Mitigating environmental BPA exposure is essential to reduce epigenetic risks for current and future generations.
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