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A rare complication of chronic granulomatous disease in a child: constrictive aspergillus pericarditis

Emrah Şişli1, Yasemin Özdemir Şahan, Mehmet Fatih Ayık

  • 1Department of Cardiovascular Surgery, Ege University Faculty of Medicine, İzmir, Turkey. dresisli@gmail.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|October 10, 2017
PubMed

Insights

Chronic granulomatous disease (CGD) patients can develop constrictive aspergillus pericarditis. Early antifungal treatment and surgery are crucial for survival in these critical cases.

Area of Science:

  • Medical Mycology
  • Immunology
  • Cardiology

Background:

  • A 3-year-old female patient with a history of chronic granulomatous disease (CGD) and autoimmune gastric outlet obstruction was admitted for bronchopneumonia and congestive heart failure.
  • Computed tomography revealed pneumonic infiltrations and pericardial thickening, suggesting cardiac involvement.

Observation:

  • Pulsed-wave Doppler showed an E/A ratio greater than 1.
  • Surgical pericardiectomy revealed thick, fibrinous exudate-filled abscesses within the pericardium.
  • Histopathology confirmed granulomatous inflammation, and Aspergillus fumigatus was isolated from the abscesses.

Findings:

  • The patient presented with a rare case of constrictive aspergillus pericarditis secondary to chronic granulomatous disease.
  • Invasive Aspergillus infection complicated the cardiac condition in an immunocompromised host.

Implications:

  • Prompt diagnosis and combined antifungal therapy with aggressive surgical intervention are vital for managing aspergillus pericarditis in CGD patients.
  • This case highlights the importance of considering invasive fungal infections in immunocompromised individuals presenting with cardiac complications.

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