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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
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Hypodense eosinophils in allergic rhinitis.

W E Frick1, J B Sedgwick, W W Busse

  • 1Department of Medicine, University of Wisconsin, Madison 53792.

The Journal of Allergy and Clinical Immunology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Hypodense eosinophils (HE), more active cells, are significantly increased in patients with allergic rhinitis (AR). This suggests HE may play a role in the development of AR symptoms.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Peripheral blood eosinophils are a heterogeneous cell population.
  • Hypodense eosinophils (HE) exhibit higher metabolic activity and potential for tissue injury.

Purpose of the Study:

  • To investigate the presence and significance of HE in patients with allergic rhinitis (AR).

Main Methods:

  • Peripheral blood samples from patients with ragweed AR and control subjects were analyzed.
  • Granulocytes were isolated and fractionated using continuous density Percoll gradients.
  • The density distribution of eosinophils was determined via centrifugation.

Main Results:

  • Patients with AR showed a significantly higher percentage of peripheral blood HE (30.0%) compared to controls (9.0%).
  • A higher percentage of HE was observed in patients with moderate-to-severe AR compared to those with mild disease.
  • The presence of HE correlated with the severity of allergic rhinitis symptoms.

Conclusions:

  • The increased circulation of HE in AR patients suggests a potential link to allergic symptom development.
  • HE's enhanced metabolic activity and association with symptomatic hay fever indicate its possible role in AR pathophysiology.