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Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
Published on: May 26, 2023
Patient Blood Management in Pediatric Cardiac Surgery: A Review
Jill M Cholette1, David Faraoni2, Susan M Goobie3,4
1From the Department of Pediatrics, Golisano Children's Hospital, University of Rochester, Rochester, New York.
Insights
Implementing comprehensive blood management strategies in pediatric cardiac surgery can reduce blood product transfusions. Further research is needed to understand the impact of these blood conservation practices on clinical outcomes in children.
Area of Science:
- Pediatric Cardiac Surgery
- Transfusion Medicine
- Critical Care Medicine
Background:
- Children undergoing cardiac surgery often require blood products due to hemostatic system alterations, hemodilution, hypothermia, and inflammation during cardiopulmonary bypass.
- Complex surgical procedures, cardiopulmonary interactions, and risks of inadequate oxygen delivery and bleeding increase blood product utilization in this population.
Purpose of the Study:
- To review current evidence on anemia management and blood transfusion practices in perioperative pediatric cardiac surgery.
- To evaluate the effectiveness of blood conservation strategies in reducing transfusions.
Main Methods:
- Systematic review of existing literature on blood management in pediatric cardiac surgery.
- Analysis of studies focusing on anemia management and transfusion practices.
Main Results:
- Comprehensive blood management approaches are associated with decreased blood product transfusions in pediatric cardiac surgery.
- Evidence suggests that safe, conservative blood management practices can be implemented across perioperative periods.
Conclusions:
- Adoption of a comprehensive blood management approach effectively reduces blood transfusions in pediatric cardiac surgery.
- The impact of these blood conservation strategies on clinical outcomes requires further investigation.
Abstract:
Efforts to reduce blood product transfusions and adopt blood conservation strategies for infants and children undergoing cardiac surgical procedures are ongoing. Children typically receive red blood cell and coagulant blood products perioperatively for many reasons, including developmental alterations of their hemostatic system, and hemodilution and hypothermia with cardiopulmonary bypass that incites inflammation and coagulopathy and requires systemic anticoagulation. The complexity of their surgical procedures, complex cardiopulmonary interactions, and risk for inadequate oxygen delivery and postoperative bleeding further contribute to blood product utilization in this vulnerable population. Despite these challenges, safe conservative blood management practices spanning the pre-, intra-, and postoperative periods are being developed and are associated with reduced blood product transfusions. This review summarizes the available evidence regarding anemia management and blood transfusion practices in the perioperative care of these critically ill children. The evidence suggests that adoption of a comprehensive blood management approach decreases blood transfusions, but the impact on clinical outcomes is less well studied and represents an area that deserves further investigation.
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