Related Experiment Videos
Fe Core-Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer.
Rakesh P Chaudhary1, Kim Kangasniemi2, Masaya Takahashi3
1Department of Physics, University of Texas at Arlington; Arlington, TX 76019, USA. rakeshpratapbhai.chaudhary@mavs.uta.edu.
Journal of Functional Biomaterials
|October 10, 2017
Summary
Researchers developed novel iron core-carbon shell nanoparticles for enhanced magnetic resonance imaging (MRI) contrast. These nanoparticles exhibit excellent dispersibility and high relaxivity, offering potential for advanced biomedical imaging applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Imaging
Background:
- Magnetic nanoparticles are crucial for enhancing contrast in Magnetic Resonance Imaging (MRI).
- Developing efficient and stable core-shell nanostructures is key for advanced biomedical applications.
- Existing MRI contrast agents often face limitations in efficacy and biocompatibility.
Purpose of the Study:
- To fabricate hybrid iron (Fe) core-carbon (C) shell nanoparticles with superior magnetic properties.
- To evaluate these nanoparticles as negative contrast agents for MRI.
- To establish a versatile and simple synthesis method for these advanced nanomaterials.
Main Methods:
- A one-step top-down approach using electric plasma discharge in an ultrasonic cavitation field.
- Synthesis conducted in organic solvents.
- Characterization via Transmission Electron Microscopy (TEM) and assessment of magnetic properties.
Main Results:
- Fabricated Fe core-C shell nanoparticles with diameters ranging from 10-85 nm.
- Observed excellent dispersibility in water without agglomeration.
- Confirmed body-centered cubic (bcc) crystal structure for Fe nanoparticles.
- Achieved a high transverse relaxivity (r₂) of 70 mM⁻¹·S⁻¹ at 7 T, indicating strong MRI contrast enhancement.
Conclusions:
- The developed Fe core-C shell nanoparticles demonstrate high efficacy as MRI contrast agents.
- The simple, one-step synthesis is versatile and scalable.
- These nanoparticles hold significant potential for various biomedical imaging and therapeutic applications.
Related Concept Videos
01:24Magnetic Resonance Imaging
10.0K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.0K
01:27Bioavailability Enhancement: Drug Permeability Enhancement
248
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
248
01:27Imaging Studies IV: Magnetic Resonance Imaging
303
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
303
01:20¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
1.8K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.8K
01:04¹³C NMR: ¹H–¹³C Decoupling
1.9K
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
1.9K
01:16Bioavailability Enhancement: Drug Solubility Enhancement
298
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
298