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Splanchnic vein thrombosis as a first manifestation of Primary myelofibrosis

Gregorio Campos-Cabrera1, Virginia Campos-Cabrera2, Salvador Campos-Cabrera1

  • 1Servicio de Hematología, Laboratorios Fátima de Michoacán, Morelia, Mich., México.

Gaceta Medica De Mexico
|October 10, 2017
PubMed

Myeloproliferative neoplasms are chronic disorders of clonal hematopoietic stem cells, characterized by an overproduction of functional granulocytes, red blood cells and / or platelets, and one of the major complications is the occurrence of venous and arterial thrombotic problems caused by increased platelet aggregation and thrombin generation. In this study 11 cases of primary myelofibrosis (PM) were evaluated and 2 debuted with splanchnic venous thrombosis (SVT); so after seeing the results of this study and of world literature, it is suggested that in patients with SVT, diagnostic methods for PM like the JAK2V617F mutation should be included.

Keywords:
JAK2V617F mutationMielofibrosis primariaMutación JAK2V617FMyeloproliferative neoplasmsNeoplasias mieloproliferativasPrimary myelofibrosisSplanchnic vein thrombosisTrombosis venosa esplácnica

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