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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
[Cerebral hydatid disease: report of six pediatric cases]
Martín Brízuela1, Claudia Sarkis1, Roberto González2
1Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría Profesor Dr. Juan P Garrahan, Chile.
Insights
Cerebral hydatid disease, caused by Echinococcus granulosus, is rare in children but presents as a single brain cyst. Prompt diagnosis and treatment lead to favorable outcomes, though neurological deficits can occur.
Area of Science:
- Parasitology
- Pediatric Neurology
- Infectious Diseases
Background:
- Hydatid disease is a parasitic infection caused by Echinococcus granulosus.
- Humans act as accidental intermediate hosts, with the liver being the most common site of infection.
- Cerebral involvement is uncommon, particularly in adults, but frequently observed in pediatric populations.
Observation:
- This study details six pediatric patients with cerebral hydatid disease presenting with neurological symptoms.
- All patients exhibited a single cystic brain lesion on imaging, with no other organ involvement detected.
- Notably, serological tests for Echinococcus granulosus were negative in all observed cases.
Findings:
- The six pediatric patients received both medical and surgical interventions for their cerebral hydatid disease.
- Five patients experienced a favorable clinical outcome with no lasting neurological deficits.
- One patient developed residual right faciobrachiocrural paresis following treatment.
Implications:
- Cerebral hydatid disease should be included in the differential diagnosis for pediatric patients presenting with cystic central nervous system lesions.
- Early recognition and management are crucial for improving patient outcomes and minimizing long-term neurological sequelae.
- The study highlights the importance of considering parasitic infections in neurological presentations, even with negative serology.
Abstract:
Hydatid disease is a parasitic infection whose etiologic agent is Echinococcus granulosus. Human is an accidental intermediate host and the most common site is the liver. The brain involvement is unusual and up to 75% of cases are described in the pediatric population. We present six children with cerebral hydatid disease admitted to the Pediatric Hospital J.P. Garrahan. All had neurological involvement on admission. The images showed single cystic lesion in the brain. They did not present involvement in other organs. Serology was negative in all cases. Medical and surgical treatment in all cases. The clinical outcome was favorable without sequelae in five of them and one had a residual paresis right faciobrachiocrural. This infection should be considered in the differential diagnosis of cystic tumor lesions of the central nervous system.
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