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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Guoyou Huang1,2, Fei Li1,2, Xin Zhao3
1MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University , Xi'an 710049, People's Republic of China.
Chemical Reviews
|October 10, 2017
Summary
The cell microenvironment, particularly its extracellular matrix (ECM), significantly influences cell behavior. Engineering 3D environments using biomimetic materials advances regenerative medicine and therapies.
Area of Science:
- Biomaterials Science
- Cell Biology
- Tissue Engineering
Background:
- The cell microenvironment is crucial for cell function in health and disease.
- The extracellular matrix (ECM) provides structural support and biochemical/biophysical cues.
- Three-dimensional (3D) microenvironments are essential for replicating in vivo cell responses.
Purpose of the Study:
- To review recent advances in engineering the 3D cell microenvironment.
- To highlight challenges and future directions in understanding cell-microenvironment interactions.
- To discuss the impact of biomimetic materials on regenerative medicine and therapies.
Main Methods:
- Review of current literature on 3D cell microenvironment engineering.
- Analysis of functional and biomimetic materials for cell culture.
- Discussion of key factors influencing cell behavior within the microenvironment.
Main Results:
- Progress in controlling cell behavior using 3D engineered environments.
- Advancements in tissue regeneration, in vitro models, and cell-based therapies.
- Identification of ongoing challenges in dissecting microenvironmental cues (chemistry, mechanics, etc.).
Conclusions:
- The field of 3D cell microenvironment engineering is rapidly evolving.
- Understanding complex cell-microenvironment interactions remains critical.
- Significant potential exists for future applications, despite current uncertainties.
