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Gastric emptying of large single unit dosage forms
S S Davis1, F Norring-Christensen, R Khosla
1Department of Pharmacy, University of Nottingham, University Park, UK.
The Journal of Pharmacy and Pharmacology
|March 1, 1988
Summary
Meal size impacts how quickly single unit dosage forms move through the gastrointestinal tract. Concurrent administration of two tablets may lead to varied gastric emptying times, affecting drug delivery.
Area of Science:
- Pharmacokinetics
- Gastrointestinal Physiology
Background:
- Understanding drug absorption and efficacy requires knowledge of gastrointestinal transit.
- Dosage form transit is influenced by physiological and meal-related factors.
Purpose of the Study:
- To investigate the gastrointestinal transit of single unit dosage forms.
- To evaluate the effect of feeding conditions on drug transit.
Main Methods:
- Healthy subjects ingested two single unit dosage forms.
- Gastrointestinal transit was monitored under varying meal conditions.
Main Results:
- The size of the administered meal significantly affected gastrointestinal transit.
- Concurrent administration of two tablets resulted in simultaneous gastric emptying in some cases.
- Significant delays or differences in gastric emptying times were observed between the two concurrently administered tablets in other cases.
Conclusions:
- Meal composition and size are critical factors influencing the gastrointestinal transit of dosage forms.
- Variability in gastric emptying for concurrently administered tablets may impact therapeutic outcomes.