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Kinetic mechanism for the intestinal absorption of ofloxacin
J G Prieto1, J P Barrio, A I Alvarez
1Laboratory of Animal Physiology, Faculty of Biology, University of Leon, Spain.
The Journal of Pharmacy and Pharmacology
|March 1, 1988
Abstract:
The absorptive behaviour of ofloxacin, a quinolone antibacterial agent, was studied following recirculation in small intestine of both male and female rats, at initial doses ranging from 0.125 to 5 mg mL-1. A saturable Michaelis-Menten process is suggested to explain the intestinal absorption. No significant differences were found in the absorption parameters per metabolic weight unit.