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The serum amyloid P response in the mouse air pouch
K M Bottomley1, T J Rising, A Steward
1Department of Drug Discovery, Hoechst UK Ltd., Walton, Milton Keynes, UK.
The Journal of Pharmacy and Pharmacology
|March 1, 1988
Abstract:
Levels of the acute phase reactant serum amyloid P (SAP) have been measured in the mouse pouch model of rheumatoid arthritis. Implantation of cartilage resulted in a significant and rapid elevation in the SAP concentration, which remained high for the duration of the experiment (14 days). Initial studies with several clinically employed antirheumatic drugs indicated that dexamethasone and cyclosporin A had a marked inhibitory effect.