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Klotho gene expression decreases in peripheral blood mononuclear cells (PBMCs) of patients with relapsing-remitting

Masoumeh Karami1, Farzad Mehrabi2, Abdolamir Allameh3

  • 1Department of Biochemistry, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.

Journal of the Neurological Sciences
|October 10, 2017
PubMed
Abstract

Insights

Klotho gene expression is significantly reduced in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. This finding suggests Klotho may play a role in MS pathogenesis and warrants further investigation.

Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genetics

Background:

  • Klotho, a protein with anti-aging and anti-inflammatory properties, is implicated in the etiology and pathogenesis of multiple sclerosis (MS).
  • Klotho's function and gene expression are modulated by inflammatory pathways, suggesting a link to MS.
  • Investigating Klotho gene expression in MS patients is crucial for understanding its role.

Purpose of the Study:

  • To investigate the gene expression of Klotho in peripheral blood mononuclear cells (PBMCs) of patients diagnosed with multiple sclerosis (MS).

Main Methods:

  • Quantitative Real-Time PCR was employed to measure Klotho mRNA levels.
  • PBMCs were isolated from blood samples of 30 relapsing-remitting MS (RRMS) patients and 30 age/sex-matched healthy controls.

Main Results:

  • Klotho gene expression in PBMCs of RRMS patients was approximately 2.5-fold lower compared to healthy individuals (P=0.0006).

Conclusions:

  • This study provides the first evidence of a potential role for Klotho in the PBMCs of multiple sclerosis patients.
  • The observed downregulation of Klotho in MS patients suggests its involvement in the disease process.
Keywords:
KlothoMultiple sclerosisPeripheral blood mononuclear cellsReal-Time PCR

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