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From supramolecular polymers to multi-component biomaterials.

Olga J G M Goor1, Simone I S Hendrikse, Patricia Y W Dankers

  • 1Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. e.w.meijer@tue.nl p.y.w.dankers@tue.nl.

Chemical Society Reviews
|October 10, 2017
PubMed
Summary
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Synthetic chemists are creating dynamic supramolecular biomaterials inspired by the extracellular matrix (ECM) for regenerative medicine. These advanced materials mimic natural tissue interactions for improved therapeutic applications.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Supramolecular Chemistry

Background:

  • Biological fibrous architectures in the extracellular matrix (ECM) exhibit strong, directional interactions and dynamic behavior.
  • The ECM's complexity inspires synthetic chemists to create artificial one-dimensional fibrous structures.
  • Supramolecular biomaterials offer dynamic properties crucial for interacting with natural tissues.

Purpose of the Study:

  • To review the translation of one-dimensional supramolecular polymers into multi-component functional biomaterials.
  • To highlight the potential of supramolecular biomaterials in regenerative medicine.
  • To discuss the design principles and applications of these biomaterials.

Main Methods:

  • Review of existing literature on supramolecular polymers and biomaterials.

Related Experiment Videos

  • Analysis of dynamic non-covalent interactions in biomaterial design.
  • Exploration of elastomeric and hydrogel systems for specific applications.

    • Main Results:

    • Supramolecular biomaterials can mimic the dynamic and interactive properties of the ECM.
    • These materials are being developed as elastomeric materials for load-bearing applications and hydrogels for cell culture.
    • Early examples of functional supramolecular biomaterials have successfully reached clinical applications.

    Conclusions:

    • Supramolecular biomaterials represent a promising frontier in regenerative medicine.
    • Their ability to adapt to cell behavior through dynamic interactions is key to their therapeutic potential.
    • Continued research in this area is expected to yield further advancements in multi-component biomaterial design.