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Related Experiment Videos

Closing the mycetoma knowledge gap.

Wendy van de Sande1, Ahmed Fahal2, Sarah Abdalla Ahmed3

  • 1ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Wytemaweg 80, 3015 CE, Rotterdam, The Netherlands.

Medical Mycology
|October 10, 2017
PubMed
Summary
This summary is machine-generated.

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Mycetoma, a neglected tropical disease, has seen significant research progress since 2013. Advances include updated prevalence maps, novel causative agents, and improved diagnostic and treatment strategies.

Area of Science:

  • Medical Mycology
  • Tropical Medicine
  • Epidemiology

Background:

  • Mycetoma was recognized as a neglected tropical disease by the WHO in 2016.
  • Global experts convened in 2013 to address knowledge gaps in mycetoma.
  • Key areas identified for research included incidence, prevalence, transmission, diagnosis, and treatment.

Purpose of the Study:

  • To review the progress made in understanding and managing mycetoma since its recognition as a neglected tropical disease.
  • To highlight advancements in closing identified knowledge gaps.
  • To discuss the path towards improved mycetoma diagnosis and treatment.

Main Methods:

  • Literature review of mycetoma research progress since 2013.
  • Analysis of updated patient data to refine prevalence mapping.

Related Experiment Videos

  • Molecular phylogenetic analysis for species identification and correction.
  • Development and evaluation of novel diagnostic techniques and treatment strategies.

    • Main Results:

    • Over 9000 new patient cases added to the literature, enabling updated mycetoma prevalence maps.
    • Four novel mycetoma causative agents identified through molecular phylogeny, with species names corrected.
    • Association found between mycetoma agents and Acacia trees.
    • Development of three isothermal amplification techniques for early diagnosis and discovery of novel antigens.
    • Establishment of in vitro susceptibility tests for black grain mycetoma agents and initiation of the first eumycetoma randomized clinical trial.

    Conclusions:

    • Significant progress has been made in mycetoma research, addressing key knowledge gaps.
    • Novel diagnostic tools and treatment approaches are emerging, offering hope for better patient outcomes.
    • Continued research and collaboration are crucial for controlling this neglected tropical disease.