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Related Experiment Videos

Nucleus accumbens shell moderates preference bias during voluntary choice behavior.

Hyeran Jang1, Kanghoon Jung1,2, Jaehoon Jeong3

  • 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

Social Cognitive and Affective Neuroscience
|October 10, 2017
PubMed
Summary

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The nucleus accumbens (NAc) shell regulates choice behavior by reducing bias toward preferred options. Lesions here increased preference bias, impacting reward system dynamics.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Decision-Making

Background:

  • The nucleus accumbens (NAc) shell is a key brain region in the reward system.
  • Its precise role in voluntary choice behavior is not fully understood.

Purpose of the Study:

  • To investigate the function of the NAc shell in modulating choice behavior.
  • To examine the effects of NAc shell lesions on motivation, preference bias, and persistence in a foraging task.

Main Methods:

  • Rats with electrolytic lesions in the NAc shell were used.
  • A novel foraging paradigm was employed over two weeks.
  • Behavioral dynamics, including motivation, preference bias, and persistence, were analyzed.

Main Results:

Keywords:
foraging decision-making behaviorinhibitory controlmesolimbic reward pathwaymotivationneurobiology of reward valuation

Related Experiment Videos

  • NAc shell lesions significantly increased preference bias, leading to over-selection of preferred food options.
  • No significant effects were observed on motivation or choice persistence.

Conclusions:

  • The NAc shell plays a crucial role in moderating instrumental valuation.
  • It acts to inhibit excessive bias towards preferred choices within the reward system.