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Hydroxyapatite functionalization to trigger adsorption and release of risedronate
Lucia Forte1, Stéphanie Sarda2, Christèle Combes3
1Department of Chemistry "G. Ciamician", University of Bologna, via Selmi 2, 40126 Bologna, Italy.
Colloids and Surfaces. B, Biointerfaces
|October 10, 2017
Summary
Functionalizing hydroxyapatite (HA) with poly-ethylenimine (PEI) enhances risedronate adsorption and modulates its release. This tailored hydroxyapatite offers potential for targeted delivery of antiresorptive agents in osteoporosis treatment.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Pharmacology
Background:
- Bisphosphonates are crucial for treating bone resorption disorders.
- Bisphosphonates exhibit strong binding to apatite, the mineral component of bone.
- Understanding drug-carrier interactions is vital for effective drug delivery.
Purpose of the Study:
- To investigate the impact of hydroxyapatite functionalization on risedronate adsorption and release.
- To compare adsorption and release profiles on pure hydroxyapatite (HA), zinc-substituted hydroxyapatite (ZnHA), and poly-ethylenimine-functionalized hydroxyapatite (HAPEI).
Main Methods:
- Synthesis of HA, ZnHA, and HAPEI materials.
- Adsorption studies of risedronate onto the different hydroxyapatite supports.
- Analysis of risedronate release kinetics from the functionalized supports.
Main Results:
- All hydroxyapatite supports followed Langmuir adsorption isotherms for risedronate.
- HAPEI showed continuous risedronate adsorption, with no plateau reached even at high concentrations.
- Risedronate adsorption on HAPEI involved both chemisorption (apatitic phase) and physisorption (PEI coating), influencing release.
Conclusions:
- Hydroxyapatite functionalization significantly influences bisphosphonate adsorption and release mechanisms.
- HAPEI demonstrates unique adsorption properties due to its mineral-organic nature.
- Tailored hydroxyapatite supports hold promise for developing localized delivery systems for antiresorptive drugs in osteoporosis.
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