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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Adjuvant therapy in renal cell carcinoma
Francesco Massari1, Vincenzo Di Nunno1, Chiara Ciccarese2
1Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy.
Cancer Treatment Reviews
|October 10, 2017
Summary
Adjuvant therapy for localized renal cell carcinoma (RCC) is under investigation. This review summarizes clinical trials of immunotherapy and targeted agents in non-metastatic RCC, highlighting their potential role in improving patient outcomes.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Metastatic renal cell carcinoma (mRCC) treatments have advanced significantly with targeted therapies and immune-checkpoint inhibitors.
- Key metabolic pathways in mRCC have been identified, leading to novel therapeutic strategies.
- Despite progress in advanced disease, the role of adjuvant therapy in localized, non-metastatic RCC is not yet established.
Purpose of the Study:
- To review current clinical trials on adjuvant therapy for renal cell carcinoma.
- To focus on the utility of immunotherapy and targeted agents in the adjuvant setting for non-metastatic RCC.
- To clarify the evolving treatment paradigm for localized kidney cancer.
Main Methods:
- Systematic review of clinical trials investigating adjuvant treatments for renal cell carcinoma.
- Focus on studies involving immunotherapy and targeted agents.
- Analysis of data pertaining to localized, non-metastatic RCC.
Main Results:
- Several targeted therapies and immune-checkpoint inhibitors show clinical activity in mRCC.
- Ongoing clinical trials are actively exploring the efficacy of these agents in the adjuvant setting.
- The precise role and benefit of adjuvant therapy in non-metastatic RCC are still under investigation.
Conclusions:
- Adjuvant immunotherapy and targeted agents represent a promising frontier in renal cell carcinoma treatment.
- Further research and clinical trials are crucial to define the standard of care for adjuvant therapy in localized RCC.
- Understanding the utility of these agents may significantly alter the management of non-metastatic kidney cancer.
Keywords:
Adjuvant treatmentClear cell renal cell carcinomaImmunotherapyRenal cell carcinomaTyrosine kinases inhibitorsMore Related Videos
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