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Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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Reflux Hypersensitivity: A New Functional Esophageal Disorder.

Takahisa Yamasaki1, Ronnie Fass1

  • 1Division of Gastroenterology and Hepatology, Esophageal and Swallowing Center, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.

Journal of Neurogastroenterology and Motility
|October 10, 2017
PubMed
Summary

Reflux hypersensitivity, a functional esophageal disorder, links heartburn to reflux events in patients with normal tests. Treatment often involves neuromodulators or surgery.

Keywords:
Chest painEsophagusFunctional esophageal disorderHeartburnReflux hypersensitivity

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Area of Science:

  • Gastroenterology
  • Functional Gastrointestinal Disorders

Background:

  • Reflux hypersensitivity is a newly defined functional esophageal disorder.
  • It affects individuals with typical heartburn symptoms despite normal diagnostic tests.
  • This condition is highly prevalent, particularly among young to middle-aged women, and often co-occurs with other functional gastrointestinal disorders and psychological comorbidities.

Purpose of the Study:

  • To define reflux hypersensitivity.
  • To outline diagnostic criteria and common patient demographics.
  • To discuss current and potential treatment strategies.

Main Methods:

  • Diagnosis involves upper endoscopy with biopsies.
  • Esophageal pH-impedance testing and high-resolution esophageal manometry are utilized.
  • Correlation between heartburn symptoms and reflux events is established.

Main Results:

  • Reflux hypersensitivity is characterized by heartburn correlating with reflux events.
  • It accounts for over 90% of PPI-refractory heartburn cases when combined with functional heartburn.
  • The condition frequently overlaps with other functional gastrointestinal disorders and psychological issues.

Conclusions:

  • Reflux hypersensitivity is a significant functional esophageal disorder.
  • Diagnosis requires a combination of endoscopic, pH-impedance, and manometry testing.
  • Esophageal neuromodulators and surgical anti-reflux management are key treatment options.