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Tp-e interval and Tp-e/QT ratio in patients with celiac disease
K Demirtaş1, Ç Yayla1, M Yüksel2
1Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
Insights
Patients with celiac disease show elevated Tp-e interval and Tp-e/QT ratios, indicating potential cardiac electrical changes. Further research is needed to determine if these findings correlate with an increased risk of ventricular arrhythmia.
Area of Science:
- Cardiology
- Gastroenterology
- Electrophysiology
Background:
- Celiac disease is an immune-mediated intestinal disorder.
- Increased prevalence of dilated cardiomyopathy and ischemic heart disease noted in celiac patients.
- Cardiac electrical activity alterations in celiac disease require further investigation.
Purpose of the Study:
- To evaluate the Tp-e interval and Tp-e/QT ratio in individuals diagnosed with celiac disease.
- To compare these electrocardiographic parameters between celiac patients and healthy controls.
- To explore potential correlations between these cardiac markers and disease characteristics.
Main Methods:
- A single-center study involving 76 participants (38 celiac disease, 38 controls).
- Electrocardiographic measurements of Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were performed.
- Data collected between January 2014 and June 2015.
Main Results:
- Significantly higher Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were observed in celiac disease patients compared to controls (p<0.001 for all).
- A positive correlation was found between Tp-e/QTc ratio and celiac disease duration (r=0.480, p=0.003).
- A significant positive correlation also existed between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001).
Conclusions:
- Celiac disease is associated with increased Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios.
- These electrocardiographic changes may signify underlying cardiac electrical remodeling in celiac patients.
- Further studies are warranted to ascertain if these electrophysiological alterations increase the risk of ventricular arrhythmias.
Objectives:
Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease.
Material And Methods:
This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects). Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.
Results:
Tp-e interval (64.2±11.0 vs. 44.5±6.0; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.13±0.02; p<0.001) and Tp-e/QTc ratio (0.16±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with celiac disease than control subjects. There was a significant positive correlation between Tp-e/QTc ratio and disease duration in patients with celiac disease (r=0.480, p=0.003) and also there was a significant positive correlation between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001).
Conclusions:
Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with celiac disease. Whether these changes increase the risk of ventricular arrhythmia deserve further studies.
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