Tp-e interval and Tp-e/QT ratio in patients with celiac disease

Area of Science:

• Cardiology
• Gastroenterology
• Electrophysiology

Background:

• Celiac disease is an immune-mediated intestinal disorder.
• Increased prevalence of dilated cardiomyopathy and ischemic heart disease noted in celiac patients.
• Cardiac electrical activity alterations in celiac disease require further investigation.

Purpose of the Study:

• To evaluate the Tp-e interval and Tp-e/QT ratio in individuals diagnosed with celiac disease.
• To compare these electrocardiographic parameters between celiac patients and healthy controls.
• To explore potential correlations between these cardiac markers and disease characteristics.

Main Methods:

• A single-center study involving 76 participants (38 celiac disease, 38 controls).
• Electrocardiographic measurements of Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were performed.
• Data collected between January 2014 and June 2015.

Main Results:

• Significantly higher Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were observed in celiac disease patients compared to controls (p<0.001 for all).
• A positive correlation was found between Tp-e/QTc ratio and celiac disease duration (r=0.480, p=0.003).
• A significant positive correlation also existed between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001).

Conclusions:

• Celiac disease is associated with increased Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios.
• These electrocardiographic changes may signify underlying cardiac electrical remodeling in celiac patients.
• Further studies are warranted to ascertain if these electrophysiological alterations increase the risk of ventricular arrhythmias.