The resting perfusion pattern associates with functional decline in type 2 diabetes.
Weiying Dai1, Wenna Duan1, Freddy J Alfaro2
1Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, USA.
Neurobiology of Aging
|October 11, 2017
Summary
Type 2 diabetes mellitus (T2DM) is linked to reduced cerebral blood flow (CBF) in key brain networks. This decline in CBF over two years correlates with worsening cognitive and mobility functions in T2DM patients.
Area of Science:
- Neurology
- Endocrinology
- Medical Imaging
Background:
- Type 2 diabetes mellitus (T2DM) is a growing global health concern.
- Cognitive impairment and mobility decline are common in T2DM patients.
- Cerebral blood flow (CBF) alterations may underlie these deficits.
Purpose of the Study:
- To investigate the relationship between CBF, cognitive function, and mobility in T2DM over two years.
- To identify specific brain regions affected by reduced CBF in T2DM.
- To explore the role of insulin resistance in CBF changes.
Main Methods:
- Seventy-three participants (41 T2DM, 32 controls) underwent volumetric CBF assessment using arterial spin labeling perfusion MRI at baseline and 2-year follow-up.
- Voxel-wise analysis identified regions with CBF differences between groups.
- Correlation analysis examined associations between regional CBF changes and cognitive/mobility performance.
Main Results:
- T2DM participants exhibited reduced CBF in default mode, visual, and cerebellum networks compared to controls.
- A greater decrease in longitudinal CBF was associated with poorer gait, memory, and executive functions.
- Higher baseline insulin resistance and worse cognitive performance were linked to reduced regional perfusion.
Conclusions:
- Impaired resting regional perfusion in T2DM is closely associated with worse cognitive and mobility outcomes.
- Insulin resistance may exacerbate regional perfusion deficits in T2DM.
- These findings highlight the importance of monitoring CBF in T2DM management.
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