Related Experiment Video

Updated: Aug 14, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation

Lingtao Jin1,2, Wenfeng Zeng1, Fayun Zhang1

  • 1Protein and Peptide Pharmaceutical Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; and.

Journal of Immunology (Baltimore, Md. : 1950)
|October 11, 2017
PubMed

Insights

Naringenin, a natural flavanone, protects against lethal inflammation by enhancing the degradation of inflammatory cytokines. This discovery offers a new therapeutic strategy for managing inflammatory diseases.

Area of Science:

  • Immunology
  • Pharmacology
  • Cell Biology

Background:

  • Acute inflammatory diseases arise from uncontrolled immune responses.
  • Therapeutic control of inflammation is vital for treating numerous human conditions.
  • Liver injury models, such as LPS- and Con A-induced, are used to study inflammation.

Purpose of the Study:

  • To investigate the protective effects of naringenin against inflammation-induced liver injury.
  • To elucidate the mechanism by which naringenin modulates inflammatory cytokine production.

Main Methods:

  • Murine models of LPS- and Con A-induced liver injury.
  • Analysis of inflammatory cytokine levels (e.g., TNF-α, IL-6).
  • Investigation of intracellular cytokine degradation pathways involving lysosomes and TFEB.

Main Results:

  • Naringenin demonstrated protection against lethality and organ injury in murine models.
  • Naringenin reduced inflammatory cytokine levels without affecting TLR signaling, mRNA stability, or protein translation.
  • Naringenin was found to enhance intracellular cytokine degradation via lysosome- and TFEB-dependent pathways.

Conclusions:

  • Naringenin effectively dampens cytokine production by regulating lysosome function.
  • Naringenin represents a potential therapeutic agent for inflammation-related diseases.
  • The study highlights a posttranslational control mechanism for cytokine regulation by naringenin.

More Related Videos

Preparation of Naringenin Solution for In Vivo Application08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

Generation of Hook Ischemia-Reperfusion Model using a Three-Day Developing Chick Embryo14:05

Generation of Hook Ischemia-Reperfusion Model using a Three-Day Developing Chick Embryo

Published on: February 19, 2022

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...