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Updated: Feb 21, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
Using Laser Interference Lithography in the Fabrication of a Simplified Micro- and Nanofluidic Device for Label-free
Taiga Ajiri1, Haruya Kasa2, Masatoshi Maeki3
1Graduate School of Chemical Sciences and Engineering, Hokkaido University.
Abstract:
Recently, we developed a label-free detection method based on optical diffraction, and implemented it in on our fabricated micro- and nanofluidic device. This detection method is simple and useful for detecting biomolecules, but the device fabrication consists of complicated processes. In this paper, we propose a simple method for fabricating the micro- and nanofluidic device; the fabrication combines laser interference lithography with conventional photolithography. The performance of a device fabricated by the proposed method is comparable to the performance of the device in our previous study.

