Related Experiment Video
Updated: Feb 21, 2026
06:20
Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
Published on: January 12, 2024
2.6K
[Malignant lymphomas of the eye]
F Fend1, D Süsskind2, C Deuter2
1Institut für Pathologie und Neuropathologie, Comprehensive Cancer Center Tübingen-Stuttgart, Universitätsklinikum Tübingen, Eberhard Karls Universität Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Deutschland. falko.fend@med.uni-tuebingen.de.
Der Pathologe
|October 11, 2017
Summary
Malignant non-Hodgkin lymphoma (NHL) rarely affects the eye. Primary vitreoretinal lymphoma (PVRL), a type of diffuse large B-cell lymphoma (DLBCL), presents subtly and requires specialized diagnosis from vitreous samples.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Malignant non-Hodgkin lymphoma (NHL) is rare in the eye and ocular adnexae.
- Intraocular lymphomas differ from adnexal lymphomas (conjunctiva, lacrimal gland, orbit) in type and origin.
- Primary intraocular lymphomas are often diffuse large B-cell lymphomas (DLBCL), considered a variant of primary CNS DLBCL.
Purpose of the Study:
- To differentiate intraocular lymphomas from adnexal lymphomas.
- To highlight the diagnostic challenges and methods for primary vitreoretinal lymphoma (PVRL).
- To emphasize the importance of novel diagnostic techniques for PVRL.
Main Methods:
- Cytological, immunocytochemical, and molecular analysis of vitreous aspirates.
- Assessment of B-cell clonality.
- Detection of MYD88 mutations.
Main Results:
- Primary vitreoretinal lymphoma (PVRL) is the most common intraocular lymphoma.
- PVRL symptoms are nonspecific, mimicking uveitis.
- Diagnostic challenges include degenerative changes, limited material, and pseudoclonality.
Conclusions:
- Accurate diagnosis of intraocular lymphoma requires distinguishing it from adnexal NHL.
- PVRL diagnosis relies on vitreous sample analysis, with challenges in interpretation.
- MYD88 mutation detection enhances diagnostic sensitivity for PVRL, necessitating rapid specimen processing and clinical collaboration.
Related Concept Videos
01:17Accessory Structures of the Eye
4.0K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.0K
01:25Glaucoma: Overview
1.5K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.5K
01:20Muscles of the Eye
4.8K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
4.8K
01:20The Retinoblastoma Gene
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.8K